Q50, an Iron-Chelating and Zinc-Complexing Agent, Improves Cardiac Function in Rat Models of Ischemia/Reperfusion-Induced Myocardial Injury
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چکیده
منابع مشابه
Effect of pre-treatment with oxytocin on cardiac enzymes in regional ischemiareperfusion injury induced in the rat heart
Introduction: Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) induced cardioprotection and its signaling pathways on lactate dehydrogenase (LDH) and creatine kinase-MB isoenzyme (CK-MB) in the anesthetized rats. Methods: Ei...
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Li, Zhihe, Jing Ying Ma, Irene Kerr, Sarvajit Chakravarty, Sundeep Dugar, George Schreiner, and Andrew A. Protter. Selective inhibition of p38 MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury. Am J Physiol Heart Circ Physiol 291: H1972–H1977, 2006. First published June 2, 2006; doi:10.1152/ajpheart.00043.2006.—p38 MAPK is activated during heart d...
متن کاملSelective inhibition of p38alpha MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury.
p38 MAPK is activated during heart diseases that might associate with myocardial damage and deterioration of cardiac function. In a rat model of myocardial injury, we have investigated cardioprotective effects of the inhibition of p38 MAPK using a novel, orally available p38alpha MAPK inhibitor. Rats were treated with N(omega)-nitro-l-arginine methyl ester (l-NAME, 40 mg.kg(-1).day(-1)) in drin...
متن کاملDoes gallic acid improve cardiac function by attenuation of oxidative stress and inflammation in an elastase-induced lung injury?
Objective(s): Cardiovascular disease has an important role in mortality caused by lung injury. Emphysema is associated with impaired pulmonary gas exchange efficiency and airflow limitation associated with small airway inflammation. The aim was to evaluate the interactions between lung injury, inflammation, and cardiovascular disease. Since gallic acid has antioxidant ...
متن کاملeffect of pre-treatment with oxytocin on cardiac enzymes in regional ischemiareperfusion injury induced in the rat heart
introduction: cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. the aim of the present study was to evaluate oxytocin (ot) induced cardioprotection and its signaling pathways on lactate dehydrogenase (ldh) and creatine kinase-mb isoenzyme (ck-mb) in the anesthetized rats. methods: eighty...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2013
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-12-1162